There are so many people bound to long term bed in their house or in the hospital settings. There are many people use plaster cast for fractures long time. They do develop muscle weakening or wasting. Most of the time they don’t recover at all. There may be visible size differences on the muscles.
One of my friend developed paraplegia following accident 3 years ago. he had one session XBODY for trial. Next day he called me and said “for the first time I felt I had a muscle after the accident.”